P1.17-24 Treatment of Ultracentral Lung Tumors with Hypofractionated Radiation Therapy

Accelerated hypofractionated radiation therapy compared to conventionally fractionated radiation therapy for the treatment of inoperable non-small cell lung cancer

BACKGROUND While conventionally fractionated radiation therapy alone is an acceptable option for poor prognostic patients with unresectable stage III NSCLC, we hypothesized that accelerated hypofractionated radiotherapy will have similar efficacy without increasing toxicity. METHODS This is a retrospective analysis of 300 patients diagnosed with stage III NSCLC treated between 1993 and 2009. ...

Hypofractionated radiation therapy for glioblastoma

Investigation of lung normal tissue doses in lung tumors radiation therapy using both gated and conventional radiotherapy

Introduction: In radiation therapy of lung tumors, respiratory motion causes target moving, so a larger margin is needed to cover the clinical target volume (CTV). With the margin increasing, a larger volume of normal tissue will be exposed to high-dose.  In this study, dosimetric parameters of normal lung tissue were compared between gated and conventional radiotherapy (RT), u...

Treatment of dogs with oral melanoma by hypofractionated radiation therapy and platinum-based chemotherapy (1987-1997).

This retrospective study in 39 dogs with incompletely resected oral melanoma examined the efficacy of hypofractionated radiation therapy and platinum-containing chemotherapy. All dogs were completely staged, with the majority of dogs classified as stage 1. Dogs received 6 weekly fractions of 6-gray (Gy) megavoltage irradiation with a cobalt-60 unit or a 4-MeV (megaelectron volts) linear acceler...

Optimizing Timing of Immunotherapy Improves Control of Tumors by Hypofractionated Radiation Therapy

The anecdotal reports of promising results seen with immunotherapy and radiation in advanced malignancies have prompted several trials combining immunotherapy and radiation. However, the ideal timing of immunotherapy with radiation has not been clarified. Tumor bearing mice were treated with 20Gy radiation delivered only to the tumor combined with either anti-CTLA4 antibody or anti-OX40 agonist...